Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MDM4 | O15151 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PYGL | P06737 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446085 | 0.85 | MDM2 (0.55) | MDM2TP53MDM4CACNA1BHSD11B1 | |
| SCHEMBL12445916 | 0.84 | MDM2 (0.44) | MDM2TP53MDM4CACNA1BHSD11B1 | |
| SCHEMBL12446087 | 0.81 | MDM2 (0.44) | MDM2TP53MDM4 | |
| SCHEMBL12446511 | 0.80 | MDM2 (0.54) | MDM2TP53MDM4 | |
| SCHEMBL18773321 | 0.78 | MDM2 (0.58) | MDM2TP53MDM4 | |
| SCHEMBL12446587 | 0.77 | LMNA (0.46) | MDM2TP53MAPT | |
| SCHEMBL7952593 | 0.77 | P2RX7 (0.40) | MDM2TP53MDM4 | |
| SCHEMBL12446512 | 0.75 | HTT (0.46) | MDM2TP53MDM4CACNA1BHSD11B1 | |
| SCHEMBL13320012 | 0.74 | MDM2 (0.76) | MDM2TP53MDM4 | |
| SCHEMBL12446594 | 0.73 | LMNA (0.53) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |