Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 9/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446085 | 0.78 | MDM2 (0.55) | HTTMDM2TP53HSD11B1CACNA1B | |
| SCHEMBL12445916 | 0.77 | MDM2 (0.44) | MDM2TP53HSD11B1CACNA1BMDM4 | |
| SCHEMBL12446107 | 0.76 | HSD11B1 (0.39) | MDM2TP53SLC9A1HSD11B1CACNA1B | |
| SCHEMBL7948520 | 0.75 | MDM2 (0.41) | MDM2TP53HSD11B1CACNA1BMDM4 | |
| SCHEMBL18773007 | 0.74 | MDM2 (0.64) | MDM2TP53MDM4 | |
| SCHEMBL12446087 | 0.74 | MDM2 (0.44) | MDM2TP53MDM4 | |
| SCHEMBL12446511 | 0.73 | MDM2 (0.54) | HTTMDM2TP53MDM4 | |
| SCHEMBL7952593 | 0.73 | P2RX7 (0.40) | HTTMDM2TP53MDM4 | |
| SCHEMBL12446587 | 0.73 | LMNA (0.46) | HTTMDM2TP53 | |
| SCHEMBL7959673 | 0.72 | MDM2 (0.46) | MDM2TP53MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011098398-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-18 | — | — | WO | disclosed |