Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446085 | 0.88 | MDM2 (0.55) | MDM2TP53MDM4HSD11B1TAAR1 | |
| SCHEMBL7948520 | 0.84 | MDM2 (0.41) | MDM2TP53MDM4HSD11B1CACNA1B | |
| SCHEMBL12446087 | 0.83 | MDM2 (0.44) | MDM2TP53MDM4 | |
| SCHEMBL12446511 | 0.82 | MDM2 (0.54) | MDM2TP53MDM4CNR1 | |
| SCHEMBL7952593 | 0.81 | P2RX7 (0.40) | MDM2TP53MDM4 | |
| SCHEMBL12446587 | 0.81 | LMNA (0.46) | MDM2TP53CNR1 | |
| SCHEMBL18773089 | 0.79 | MDM2 (0.60) | MDM2TP53MDM4 | |
| SCHEMBL12446512 | 0.77 | HTT (0.46) | MDM2TP53MDM4HSD11B1CACNA1B | |
| SCHEMBL12446594 | 0.75 | LMNA (0.53) | POLB | |
| SCHEMBL7959673 | 0.74 | MDM2 (0.46) | MDM2TP53MDM4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011098398-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-18 | — | — | WO | disclosed |