Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963905 | 0.91 | DRD2 (0.59) | DRD2ADRA1AMEN1CACNA1FKCNK2 | |
| SCHEMBL7960076 | 0.86 | DRD2 (0.70) | DRD2ADRA1AMEN1CACNA1FKCNK2 | |
| SCHEMBL7957165 | 0.84 | DRD2 (0.66) | DRD2ADRA1AABCB11CYP3A4CYP2D6 | |
| SCHEMBL8568581 | 0.84 | OPRM1 (0.63) | DRD2HTR1AADRB3ADRA2BADRA2C | |
| SCHEMBL7949042 | 0.84 | CCR1 (0.52) | DRD2 | |
| SCHEMBL7961473 | 0.83 | DRD2 (0.58) | DRD2ADRA1AMEN1CACNA1FKCNK2 | |
| SCHEMBL7963517 | 0.80 | CCR1 (0.54) | DRD2ADRA1AKMT2A | |
| SCHEMBL7960236 | 0.79 | DRD2 (0.63) | DRD2ADRA1ADRD4DRD3 | |
| SCHEMBL7949623 | 0.79 | DRD2 (0.63) | DRD2ADRA1AMEN1CACNA1FKCNK2 | |
| SCHEMBL3851778 | 0.78 | DRD2 (0.52) | DRD2HTR1ADRD1DRD5SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |