Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563591 | 0.80 | SIGMAR1 (0.49) | SIGMAR1KCNH2CYP2D6DRD2HTR1A | |
| SCHEMBL7964141 | 0.70 | SIGMAR1 (0.48) | SIGMAR1SLC6A4DRD2HTR1ADRD3 | |
| SCHEMBL5771928 | 0.70 | DRD2 (0.43) | SIGMAR1SLC6A4DRD2HTR1ADRD3 | |
| SCHEMBL5776753 | 0.70 | MAPT (0.42) | SIGMAR1KCNH2SLC6A4DRD2DRD3 | |
| SCHEMBL5988317 | 0.68 | KCNH2 (0.88) | SIGMAR1KCNH2CYP2D6SLC6A4DRD2 | |
| SCHEMBL7718541 | 0.68 | SIGMAR1 (1.00) | SIGMAR1KCNH2CYP2D6DRD2HTR1A | |
| SCHEMBL5776684 | 0.68 | SIGMAR1 (0.53) | SIGMAR1KCNH2CYP2D6DRD2HTR1A | |
| SCHEMBL7959526 | 0.68 | MPO (0.55) | SIGMAR1KCNH2CYP2D6MPOSLC6A4 | |
| SCHEMBL5772832 | 0.68 | SIGMAR1 (0.53) | SIGMAR1KCNH2CYP2D6DRD2HTR1A | |
| SCHEMBL4528457 | 0.67 | KCNH2 (1.00) | SIGMAR1KCNH2CYP2D6DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |