Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961060 | 0.88 | HTR1A (0.54) | MPOSLC6A4SIGMAR1HTR1DHTR1B | |
| SCHEMBL7960011 | 0.88 | SIGMAR1 (0.52) | SLC6A4SIGMAR1HTR1DHTR1BDRD2 | |
| SCHEMBL7961169 | 0.88 | MAPT (0.45) | MPOSLC6A4HTR1DHTR1BDRD2 | |
| SCHEMBL5414463 | 0.83 | MPO (0.47) | MPOSIGMAR1HTR1DHTR1BDRD2 | |
| SCHEMBL5396500 | 0.82 | MAPT (0.49) | MPOSIGMAR1HTR1DHTR1BDRD2 | |
| SCHEMBL5402430 | 0.81 | HTR1D (0.45) | MPOSIGMAR1HTR1DHTR1BDRD2 | |
| SCHEMBL6613728 | 0.79 | SIGMAR1 (0.44) | MPOSLC6A4SIGMAR1HTR1DHTR1B | |
| SCHEMBL8473506 | 0.79 | ALB (0.56) | MPOSLC6A4SIGMAR1KCNH2HTR1D | |
| SCHEMBL6601965 | 0.77 | SPHK1 (0.40) | MPOHTR1DHTR1BDRD2HTR1A | |
| SCHEMBL11832241 | 0.76 | HTR1A (0.82) | MPOSLC6A4HTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |