Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28261467 | 0.80 | HSD17B10 (0.55) | TDP1L3MBTL1HSD17B10HTR1AKDM4E | |
| SCHEMBL24575662 | 0.80 | TDP1 (0.53) | TDP1L3MBTL1ACHE | |
| SCHEMBL6504771 | 0.79 | L3MBTL1 (0.55) | TDP1L3MBTL1HSD17B10HTR1AACHE | |
| SCHEMBL8178771 | 0.76 | TDP1 (0.62) | TDP1L3MBTL1HSD17B10ACHE | |
| SCHEMBL8178781 | 0.76 | TDP1 (0.62) | TDP1L3MBTL1HSD17B10KDM4ECYP1A2 | |
| SCHEMBL10956675 | 0.76 | TDP1 (0.61) | TDP1L3MBTL1HSD17B10HTR1AKDM4E | |
| SCHEMBL8189201 | 0.76 | TDP1 (0.66) | TDP1L3MBTL1CYP1A2ACHE | |
| SCHEMBL8079751 | 0.76 | LMNA (0.55) | TDP1L3MBTL1HSD17B10HTR1AKDM4E | |
| SCHEMBL29263618 | 0.75 | HSD17B10 (0.77) | TDP1L3MBTL1HSD17B10HTR1AKDM4E | |
| SCHEMBL7949955 | 0.75 | CCR1 (0.50) | TDP1L3MBTL1HSD17B10KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258941-B1 | METAL COMPLEX COVALENTLY LINKED TO NUCLEOSIDE, NUCLEOTIDE, OR OLIGONUCLEOTIDE; COMPLEX IS CAPABLE OF HYDROLYZING RNA; SYNTHETIC RIBOZYMES/ANTISENSE AGENTS FOR GENE EXPRESSION INHIBITION | WASHINGTON UNIVERSITY | 2001-07-10 | — | — | US | disclosed |
| WO-1991019730-A1 | RNA HYDROLYSIS/CLEAVAGE | MONSANTO COMPANY (US) | 1991-12-26 | — | — | WO | disclosed |