Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950570 | 0.79 | SLC1A1 (0.43) | SLC1A1PLAUPLATALDH1A1HPGD | |
| SCHEMBL8770455 | 0.72 | P2RX7 (0.43) | ALDH1A1HPGDLMNAKMT2ABCHE | |
| SCHEMBL7961908 | 0.72 | SLC1A1 (0.55) | SLC1A1ROCK2KMT2AMAOBPPARG | |
| SCHEMBL7950818 | 0.72 | TDP1 (0.42) | ALDH1A1LMNABCHEACHE | |
| SCHEMBL10069421 | 0.71 | SLC1A1 (0.60) | SLC1A1ROCK2MAOBPKMPPARG | |
| SCHEMBL21417397 | 0.71 | SLC1A1 (0.60) | SLC1A1ROCK2MAOBPKMPPARG | |
| SCHEMBL776918 | 0.71 | ALDH1A1 (0.50) | ALDH1A1BCHEACHEMAOBPKM | |
| SCHEMBL10811604 | 0.70 | MMP9 (0.40) | ALDH1A1HPGDLMNAKMT2APKM | |
| SCHEMBL5843078 | 0.69 | CYP19A1 (0.46) | ALDH1A1LMNAKMT2ABCHEACHE | |
| SCHEMBL7723991 | 0.69 | ALDH1A1 (0.46) | ALDH1A1BCHEACHEPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |