Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 11/20 | 0.40 |
| ▸ | MMP2 | P08253 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942802 | 0.85 | MMP1 (0.44) | ADAM17MMP1MMP13MMP2MMP9 | |
| SCHEMBL7950401 | 0.82 | MMP1 (0.50) | ADAM17MMP1MMP13MMP2MMP9 | |
| SCHEMBL7363680 | 0.79 | ADAM17 (0.55) | ADAM17MMP1MMP13MMP2MMP14 | |
| SCHEMBL7355311 | 0.79 | MMP13 (0.54) | ADAM17MMP1MMP13MMP2MMP14 | |
| SCHEMBL7424285 | 0.77 | ADAM17 (0.43) | ADAM17MMP1MMP13MMP2MEN1 | |
| SCHEMBL7427223 | 0.76 | ADAM17 (0.42) | ADAM17MMP1MMP13MMP2MEN1 | |
| SCHEMBL7427244 | 0.76 | ADAM17 (0.42) | ADAM17MMP1MMP13MMP2MEN1 | |
| SCHEMBL7424174 | 0.75 | ADAM17 (0.40) | ADAM17MMP1MMP13MMP2MEN1 | |
| SCHEMBL7358650 | 0.67 | ADAM17 (0.61) | ADAM17MMP1MMP13MMP2MMP14 | |
| SCHEMBL7354231 | 0.64 | ADAM17 (0.62) | ADAM17MMP1MMP13MMP2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268379-B1 | Substituted aryl hydroxamic acids as metalloproteinase inhibitors | DUPONT PHARMACEUTICALS COMPANY | 2001-07-31 | — | — | US | claimed |
| US-6268379-B1 | Substituted aryl hydroxamic acids as metalloproteinase inhibitors | DUPONT PHARMACEUTICALS COMPANY | 2001-07-31 | — | — | US | disclosed |