Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951439 | 0.89 | GAA (0.48) | GAA | |
| SCHEMBL8268993 | 0.84 | GAA (0.51) | GAA | |
| SCHEMBL11038245 | 0.78 | GAA (0.53) | GAA | |
| SCHEMBL15906664 | 0.72 | GAA (0.57) | GAA | |
| SCHEMBL5044573 | 0.71 | GAA (0.60) | GAA | |
| SCHEMBL9214465 | 0.70 | GAA (0.55) | GAA | |
| SCHEMBL9214873 | 0.70 | GAA (0.48) | GAAKDM4E | |
| SCHEMBL11041593 | 0.67 | GAA (0.51) | GAAKDM4E | |
| SCHEMBL21550076 | 0.66 | GAA (0.50) | GAA | |
| SCHEMBL13615982 | 0.65 | BRD4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135861-A1 | Process for the synthesis of the 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and its application to the synthesis of ivabradine as well as its addition salts with a pharmaceutically acceptable acid | Les Laboratoires Servier (FR) | 2009-12-23 | — | — | EP | disclosed |
| WO-2009153461-A2 | NOVEL METHOD FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE, AND USE IN THE SYNTHESIS OF IVABRADINE AND OF ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID | LES LABORATOIRES SERVIER (FR) | 2009-12-23 | — | — | WO | disclosed |