Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12936090 | 0.73 | KDM4E (0.33) | ALDH1A1KDM4E | |
| SCHEMBL6841716 | 0.72 | SMN1; SMN2 (0.34) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL4546154 | 0.72 | HSP90AA1 (0.36) | ALDH1A1 | |
| SCHEMBL312454 | 0.70 | — | — | |
| SCHEMBL8830029 | 0.69 | HSP90AA1 (0.34) | — | |
| SCHEMBL192045 | 0.69 | HSP90AA1 (0.34) | — | |
| SCHEMBL5894620 | 0.69 | KDM4E (0.34) | ALDH1A1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL3562505 | 0.67 | GPR84 (0.36) | ACHEALDH1A1MAPK1 | |
| SCHEMBL20822276 | 0.67 | SOS1 (0.31) | — | |
| SCHEMBL1044124 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107235961-A | A kind of preparation method of esomeprazole | 武汉励合生物医药科技有限公司 | 2017-10-10 | — | — | CN | claimed |
| CN-107235961-A | A kind of preparation method of esomeprazole | 武汉励合生物医药科技有限公司 | 2017-10-10 | — | — | CN | disclosed |
| CN-103880741-A | Preparation method of 2-chloromethyl-3,5-dimethyl-4-alkoxypyridyl-N-oxide | ANHUI COSTAR BIO CHEMICAL CO LTD | 2014-06-25 | — | — | CN | disclosed |
| US-6303787-B1 | STARTING FROM 4-NITRO-2,3,5-TRIMETHYLPYRIDINE-N-OXIDE AND5-METHOXY-2-MERCAPTO BENZIMIDAZOLE | NATCO PHARMA LIMITED (IN) | 2001-10-16 | — | — | US | disclosed |
| EP-1005457-A1 | PREPARATION OF PYRIDINE DERIVATIVES | Seal Sands Chemicals Limited (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010326-A1 | PREPARATION OF PYRIDINE DERIVATIVES | SEAL SANDS CHEMICALS LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| US-5066810-A | 3,5-DIMETHYL-4-METHOXYPYRIDINE DERIVATIVES | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-11-19 | — | — | US | disclosed |
| CN-1042705-A | 3,5-dimethyl-4-methoxypyridine derivatization method and be used for the novel intermediate product of this method for making | CL PHARMA (AT) | 1990-06-06 | — | — | CN | disclosed |
| EP-0103553-B1 | INTERMEDIATES FOR THE PREPARATION OF OMEPRAZOLE | Aktiebolaget Hässle (SE) | 1989-02-22 | — | — | EP | disclosed |
| US-4620008-A | Processes for the preparation of omeprazole and intermediates therefore | AKTIEBOLAGET HASSLE (SE) | 1986-10-28 | — | — | US | disclosed |
| US-4544750-A | Certain pyridyl-N-oxide intermediates for the preparation of omeprazole | AKTIEBOLAGET HASSLE (SE) | 1985-10-01 | — | — | US | disclosed |
| EP-0103553-A1 | Intermediates for the preparation of omeprazole | Aktiebolaget Hässle (SE) | 1984-03-21 | — | — | EP | disclosed |