⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10073213 | 0.75 | GPR84 (0.32) | — | |
| SCHEMBL3395408 | 0.71 | — | — | |
| SCHEMBL20822276 | 0.71 | SOS1 (0.31) | — | |
| SCHEMBL2111397 | 0.69 | — | — | |
| SCHEMBL11071521 | 0.69 | — | — | |
| SCHEMBL7951653 | 0.67 | ACHE (0.33) | — | |
| SCHEMBL14088910 | 0.67 | LMNA (0.30) | — | |
| SCHEMBL11956553 | 0.65 | — | — | |
| SCHEMBL20822264 | 0.65 | TSHR (0.36) | — | |
| SCHEMBL3639631 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646425-B1 | Indanyloxydihydrobenzofuranylacetic acids useful for the treatment of metabolic syndrome | BOEHRINGER INGELHEIM INT (DE) | 2015-06-10 | — | — | EP | disclosed |
| US-8835423-B2 | Azepine inhibitors of janus kinases | INCYTE CORPORATION (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140031344-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2014-01-30 | — | — | US | disclosed |
| US-8563541-B2 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION (US) | 2013-10-22 | — | — | US | disclosed |
| EP-2646425-A1 | INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS | Boehringer Ingelheim International GmbH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-8349222-B2 | Twisted π-electron system chromophore compounds with very large molecular hyperpolarizabilities and related compositions and devices | NORTHWESTERN UNIVERSITY (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120329782-A1 | AZEPINE INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120302566-A1 | INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-29 | — | — | US | disclosed |
| US-20120302566-A1 | INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-29 | — | — | US | disclosed |
| WO-2012072691-A1 | INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | WO | disclosed |
| US-20070149506-A1 | Azepine inhibitors of Janus kinases | INCYTE CORPORATION | 2007-06-28 | — | — | US | disclosed |
| WO-2007038215-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| CN-1882589-A | Novel heterocyclic compounds as HSP 90-inhibitors | CONFORMA THERAPEUTICS CORP (US) | 2006-12-20 | — | — | CN | disclosed |
| US-20060237368-A1 | Twisted pi-electron system chromophore compounds with very large molecular hyperpolarizabilities and related compositions and devices | NATIONAL SCIENCE FOUNDATION | 2006-10-26 | — | — | US | disclosed |
| WO-2006102620-A2 | TWISTED π-ELECTRON SYSTEM CHROMOPHORE COMPOUNDS WITH VERY LARGE MOLECULAR HYPERPOLARIZABILITIES AND RELATED COMPOSITIONS AND DEVICES | NORTHWESTERN UNIVERSITY (US) | 2006-09-28 | — | — | WO | disclosed |
| US-6806371-B2 | BY MEANS OF PHASE TRANSFER CATALYSIS | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2004-10-19 | — | — | US | disclosed |
| CN-1493561-A | Preparation of substituted pyridine N-oxide compound | DSM精细化学奥地利NFG两合公司 | 2004-05-05 | — | — | CN | disclosed |
| US-20040063957-A1 | Preparation of substituted pyridine N-oxide compounds | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2004-04-01 | — | — | US | disclosed |
| EP-1005457-A1 | PREPARATION OF PYRIDINE DERIVATIVES | Seal Sands Chemicals Limited (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010326-A1 | PREPARATION OF PYRIDINE DERIVATIVES | SEAL SANDS CHEMICALS LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |