Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4546154 | 0.79 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL2111283 | 0.76 | HDAC8 (0.30) | — | |
| SCHEMBL192671 | 0.76 | CA2 (0.33) | — | |
| SCHEMBL2111129 | 0.72 | — | — | |
| SCHEMBL714637 | 0.70 | — | — | |
| SCHEMBL11116745 | 0.69 | HSP90AA1 (0.32) | HSP90AA1HSP90AB1 | |
| SCHEMBL7951653 | 0.69 | ACHE (0.33) | — | |
| SCHEMBL311495 | 0.68 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1 | |
| SCHEMBL8830029 | 0.68 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL8346428 | 0.66 | AR (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402349-B1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2016-04-06 | — | — | EP | disclosed |
| EP-2402349-B1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2016-04-06 | — | — | EP | disclosed |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-18 | — | — | US | disclosed |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-18 | — | — | US | disclosed |
| EP-2810945-A1 | Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative | Daiichi Sankyo Company, Limited (JP) | 2014-12-10 | — | — | EP | disclosed |
| EP-2810945-A1 | Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative | Daiichi Sankyo Company, Limited (JP) | 2014-12-10 | — | — | EP | disclosed |
| US-8846703-B2 | Crystal of a free tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-09-30 | — | — | US | disclosed |
| US-8846703-B2 | Crystal of a free tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-09-30 | — | — | US | disclosed |
| US-8815880-B2 | Crystal of tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815880-B2 | Crystal of tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8236813-B2 | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-07 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158638-B2 | Pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| EP-2402349-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-04 | — | — | EP | disclosed |
| EP-2065388-B1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2011-09-07 | — | — | EP | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2065388-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113410-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885 |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | HSP90AB2P, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 4/4885 |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.