Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949715 | 0.90 | PGR (0.40) | POLBRXFP1APOBEC3GPGRMAPK8 | |
| SCHEMBL7941792 | 0.85 | SMN1; SMN2 (0.43) | POLBRXFP1PGRSMN1; SMN2MAPK1 | |
| SCHEMBL7941798 | 0.85 | PGR (0.46) | PGRMAPK1MAPK8GAA | |
| SCHEMBL7949717 | 0.84 | MAPT (0.53) | RXFP1SMN1; SMN2MAPK1ADORA3TP53 | |
| SCHEMBL7951665 | 0.83 | LMNA (0.40) | PGRSMN1; SMN2MAPK1ADORA3MAPK8 | |
| SCHEMBL7941785 | 0.83 | LMNA (0.39) | POLBRXFP1APOBEC3GPGRSMN1; SMN2 | |
| SCHEMBL7949731 | 0.83 | HSP90AA1 (0.41) | POLBPGRSMN1; SMN2MAPK1ADORA3 | |
| SCHEMBL7953535 | 0.82 | METAP2 (0.47) | POLBPGRADORA3TP53CTSV | |
| SCHEMBL7953520 | 0.82 | MAPT (0.42) | POLBPGRSMN1; SMN2ADORA3CTSV | |
| SCHEMBL7953532 | 0.82 | MAPT (0.51) | SMN1; SMN2MAPK1ADORA3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268496-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS | NEUROGEN CORPORATION | 2001-07-31 | — | — | US | claimed |
| EP-0555391-B1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2000-07-12 | — | — | EP | claimed |
| EP-0555391-A1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-08-18 | — | — | EP | claimed |
| US-5130430-A | Anxiety, sleep disorders or seizures | NEUROGEN CORPORATION (US) | 1992-07-14 | — | — | US | claimed |
| WO-1992007853-A1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-05-14 | — | — | WO | claimed |
| US-6268496-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS | NEUROGEN CORPORATION | 2001-07-31 | — | — | US | disclosed |
| EP-0555391-B1 | CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5744602-A | PSYCHOLOGICAL DISORDERS, ANTICONVULSANTS | NEUROGEN CORPORATION (US) | 1998-04-28 | — | — | US | disclosed |
| US-5130430-A | Anxiety, sleep disorders or seizures | NEUROGEN CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |