SCHEMBL7951802

SCHEMBL7951802

CCNC(=O)c1ccc(C(F)(F)F)cc1-c1ccc(OC)c(OC)c1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 1/20 0.52
LMNA P02545 1/20 0.50
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
PTGDR2 Q9Y5Y4 1/20 0.46
MAPT P10636 2/20 0.46
TRPV1 Q8NER1 1/20 0.45
PPARA Q07869 11/20 0.44
PPARG P37231 6/20 0.44
PPARD Q03181 6/20 0.44
PSEN1 P49768 2/20 0.44
PSEN2 P49810 2/20 0.44
APH1B Q8WW43 2/20 0.44
NCSTN Q92542 2/20 0.44
APH1A Q96BI3 2/20 0.44
PSENEN Q9NZ42 2/20 0.44
MCHR1 Q99705 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1395234 0.83 KDM4E (0.51) LMNANPC1RAB9APTGDR2MAPT
SCHEMBL8997635 0.82 HTT (0.51) PRKCZLMNANPC1PTGDR2MAPT
SCHEMBL6061977 0.81 PDE4B (0.58) LMNAPTGDR2TRPV1MCHR1
SCHEMBL41599 0.81 SCN9A (0.47) PTGDR2MAPTTRPV1MCHR1
SCHEMBL29158810 0.79 PPARA (0.46) PRKCZLMNAMAPTPPARAPPARG
SCHEMBL30740963 0.78 MAPT (0.44) PRKCZLMNAMAPTPPARAPPARG
SCHEMBL2099471 0.75 ABCB11 (0.56) PTGDR2PPARAPPARGPPARD
SCHEMBL8751493 0.73 MAPT (0.56) PRKCZLMNANPC1MAPT
SCHEMBL30106334 0.73 MAPT (0.47) PRKCZMAPTTRPV1
SCHEMBL4455829 0.73 P2RX1 (0.46) NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773720-A1 FUNGICIDAL COMPOSITION INCLUDING A 2-IMIDAZOLINE-5-ONE RHONE-POULENC AGROCHIMIE (FR) 1997-05-21 EP claimed
WO-1996003044-A1 FUNGICIDAL COMPOSITION INCLUDING A 2-IMIDAZOLINE-5-ONE RHONE POULENC AGROCHIMIE (FR) 1996-02-08 WO claimed
EP-0648416-A1 Fungicidal combinations based on a phenylbenzamide RHONE-POULENC AGROCHIMIE (FR) 1995-04-19 EP claimed
US-6255352-B1 TREATING FUNGI, PLANTS, SOIL OR SEEDS WITH DOSAGE OF A BISOXIME DERIVATIVE BASF AKTIENGESELLSCHAFT (DE) 2001-07-03 US disclosed
US-6232317-B1 DERIVATIVES OF 4-PHENYL-2,3-DIHYDROISOXAZOLONE AND 4-PHENYL-2,4-DIHYDROTRIAZOLONES HAVING METHYLENEOXIMINO GROUP ORTHO POSITION AND PROCESS OF MAKING THEM BY OXIMINATION, OXIDATION, AND HALOGENATION BASF AKTIENGESELLSCHAFT (DE) 2001-05-15 US disclosed
EP-0773720-A1 FUNGICIDAL COMPOSITION INCLUDING A 2-IMIDAZOLINE-5-ONE RHONE-POULENC AGROCHIMIE (FR) 1997-05-21 EP disclosed
WO-1996003044-A1 FUNGICIDAL COMPOSITION INCLUDING A 2-IMIDAZOLINE-5-ONE RHONE POULENC AGROCHIMIE (FR) 1996-02-08 WO disclosed
EP-0648416-A1 Fungicidal combinations based on a phenylbenzamide RHONE-POULENC AGROCHIMIE (FR) 1995-04-19 EP disclosed