Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | GLA | P06280 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960224 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1LMNATSHRHPGD | |
| SCHEMBL5544959 | 0.71 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1HPGDKDM4EUSP2 | |
| SCHEMBL3370074 | 0.67 | HSD17B10 (0.59) | ALDH1A1HSD17B10RAB9ALMNATSHR | |
| SCHEMBL4124403 | 0.66 | NCEH1 (0.55) | ALDH1A1HSD17B10RAB9ATSHRHPGD | |
| SCHEMBL7951898 | 0.66 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL4960213 | 0.65 | NCEH1 (0.42) | ALDH1A1HSD17B10RAB9ATSHRHPGD | |
| SCHEMBL9939750 | 0.63 | SMN1; SMN2 (0.57) | SMN1; SMN2 | |
| SCHEMBL8194166 | 0.63 | SIRT2 (0.31) | SMN1; SMN2ALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL8025929 | 0.62 | SMN1; SMN2 (0.51) | SMN1; SMN2 | |
| SCHEMBL7951873 | 0.60 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1RAB9ALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |