SCHEMBL7952

SCHEMBL7952

COc1ccccc1[C](c1ccccc1)c1ccccc1OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.58
NPC1 O15118 3/20 0.58
ALDH1A1 P00352 3/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
MAPT P10636 1/20 0.50
CA12 O43570 1/20 0.50
CA4 P22748 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
HTT P42858 2/20 0.48
CTSD P07339 1/20 0.48
KDM4E B2RXH2 1/20 0.47
LMNA P02545 1/20 0.47
KMT2A Q03164 1/20 0.47
TP53 P04637 2/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9101 0.96 RAB9A (0.58) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL8471103 0.91 TP53 (0.53) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL8474959 0.86 MAPT (0.56) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL157181 0.86 CA1 (0.60) RAB9ANPC1CA1CA2CA12
SCHEMBL10321909 0.84 KMT2A (0.50) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL9253579 0.82 NPC1 (0.50) RAB9ANPC1KCNK3KCNK9HTT
SCHEMBL28674881 0.81 NPC1 (0.61) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL10971977 0.79 NPC1 (0.54) RAB9ANPC1ALDH1A1CA1CA2
SCHEMBL50229 0.79 MAPT (0.64) RAB9ANPC1ALDH1A1MAPTKCNK3
SCHEMBL29573531 0.79 MAPT (0.64) RAB9ANPC1ALDH1A1MAPTKCNK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22913 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118290429-A Preparation method of non-zolpidem intermediate and non-zolpidem 山东百诺医药股份有限公司 2024-07-05 CN claimed
US-20240218365-A1 FORMULATION OF AN ANTISENSE OLIGOMER CONJUGATE THE PROGERIA RESEARCH FOUNDATION, INC. 2024-07-04 US claimed
EP-4392558-A1 ANTISENSE OLIGONUCLEOTIDES HAVING ONE OR MORE ABASIC UNITS Sarepta Therapeutics, Inc. (US) 2024-07-03 EP claimed
CN-118284609-A Process for preparing triazolopyrimidinone derivatives ST制药株式会社 2024-07-02 CN claimed
CN-118265786-A Microtubule-associated protein Tau (MAPT) iRNA pharmaceutical compositions and methods of use thereof 阿尔尼拉姆医药品有限公司 2024-06-28 CN claimed
US-20240209373-A1 ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 1 (ELOVL1) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US claimed
US-20240209029-A1 ADIPONECTIN GLYCOPEPTIDES AND COMPOSITIONS AND METHODS OF USE THEREOF THE UNIVERSITY OF HONG KONG (CN) 2024-06-27 US claimed
US-20240209016-A1 FLUORESCENT NUCLEOSIDE PHOSPHATES STEALTH LABELS BIOTECH AB (SE) 2024-06-27 US claimed
US-20240209018-A1 UNIVERSAL LINKER REAGENTS FOR DNA SYNTHESIS GENSCRIPT USA INC. 2024-06-27 US claimed
US-20240209374-A1 iRNA COMPOSITIONS AND METHODS FOR SILENCING CHITINASE 3-LIKE PROTEIN 1/YKL-40 (CHI3L1/YKL-40) PROTEIN ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-27 US claimed
EP-0180945-A2 Nucleotide derivative WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1986-05-14 EP claimed
EP-0135587-A4 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1986-04-02 EP claimed
EP-0064796-B1 PHOSPHORYLATING AGENT AND PROCESS FOR THE PHOSPHORYLATION OF ORGANIC HYDROXYL COMPOUNDS UNILEVER N.V. (NL) 1985-05-15 EP claimed
EP-0135587-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1985-04-03 EP claimed
WO-1984003285-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS MOLECULAR BIOSYSTEMS INC (US) 1984-08-30 WO claimed
US-4458066-A BOUND TO INORGANIC SUPPORT UNIVERSITY PATENTS, INC. (US) 1984-07-03 US claimed
US-4401796-A PHOSPHORYLATION OF A NUCLEOSIDE TO OBTAIN A MONOTRIAZOLIDE; REACTING WITH A MODIFIED RESIN SUPPORT; HYDROLYSIS CITY OF HOPE RESEARCH INSTITUTE (US) 1983-08-30 US claimed
US-4373071-A RESIN SUPPORTS; GENETIC ENGINEERING CITY OF HOPE RESEARCH INSTITUTE (US) 1983-02-08 US claimed
EP-0058563-A1 Lyophilized phosphorylated nucleosides ens BIO LOGICALS INC. (CA) 1982-08-25 EP claimed
EP-0035719-A2 Process for producing modified inorganic polymers, their use in producing polynucleotides, and a reagent useful in these processes UNIVERSITY PATENTS, INC. (US) 1981-09-16 EP claimed