SCHEMBL157181

SCHEMBL157181

COc1ccccc1[C](c1ccccc1OC)c1ccccc1OC

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.60
CA2 P00918 3/20 0.60
CA7 P43166 2/20 0.60
CA9 Q16790 2/20 0.60
CA12 O43570 1/20 0.60
CA4 P22748 1/20 0.60
CA14 Q9ULX7 1/20 0.60
CTSD P07339 1/20 0.55
TP53 P04637 2/20 0.54
TSHR P16473 1/20 0.54
STAT3 P40763 1/20 0.52
NPC1 O15118 4/20 0.50
RAB9A P51151 2/20 0.50
HTT P42858 2/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
ENPP2 Q13822 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.49
MEN1 O00255 1/20 0.49
GAA P10253 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3854662 0.87 KMT2A (0.53) CA1CA2CA7CA9CA12
SCHEMBL4077898 0.87 SMN1; SMN2 (0.54) CA1CA2CA7CA9CA12
SCHEMBL6225170 0.87 CA1 (0.46) CA1CA2CA7CA9CA12
SCHEMBL3862642 0.87 KMT2A (0.53) CA1CA2CA7CA9CA12
SCHEMBL9101 0.86 RAB9A (0.58) CA1CA2CA7CA9CA12
SCHEMBL7952 0.86 RAB9A (0.58) CA1CA2CA7CA9CA12
SCHEMBL383152 0.84 POLB (0.51) CTSDRAB9AHTTSMN1; SMN2MEN1
SCHEMBL2119268 0.82 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL3277622 0.82 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL322168 0.80 CTSD (0.62) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1982 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240218365-A1 FORMULATION OF AN ANTISENSE OLIGOMER CONJUGATE THE PROGERIA RESEARCH FOUNDATION, INC. 2024-07-04 US claimed
EP-4392558-A1 ANTISENSE OLIGONUCLEOTIDES HAVING ONE OR MORE ABASIC UNITS Sarepta Therapeutics, Inc. (US) 2024-07-03 EP claimed
US-20240209016-A1 FLUORESCENT NUCLEOSIDE PHOSPHATES STEALTH LABELS BIOTECH AB (SE) 2024-06-27 US claimed
EP-4387676-A2 DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES Sarepta Therapeutics, Inc. (US) 2024-06-26 EP claimed
WO-2024114776-A1 BICYCLIC ABASIC NUCLEIC ACID ANALOGS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 上海舶望制药有限公司 2024-06-06 WO claimed
CN-118019847-A Antisense oligonucleotides with one or more abasic units 萨勒普塔医疗公司 2024-05-10 CN claimed
WO-2024097822-A1 FORMULATION OF AN ANTISENSE OLIGOMER CONJUGATE SAREPTA THERAPEUTICS, INC. (US) 2024-05-10 WO claimed
WO-2024064237-A2 DMD ANTISENSE OLIGONUCLEOTIDE-MEDIATED EXON SKIPPING EFFICIENCY SAREPTA THERAPEUTICS, INC. (US) 2024-03-28 WO claimed
EP-3464306-B1 PROCESSES FOR PREPARING PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS SAREPTA THERAPEUTICS INC (US) 2024-03-27 EP claimed
EP-4323373-A1 FLUORESCENT NUCLEOSIDE PHOSPHATES STEALTH LABELS BIOTECH AB (SE) 2024-02-21 EP claimed
US-RE34069-E PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES BIOSYNTECH GMBH (DE) 1992-09-15 US claimed
EP-0456514-A1 2-Fluoroneplanocin A and its production ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1991-11-13 EP claimed
EP-0135587-B1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS SYNGENE, INC. (US) 1990-05-02 EP claimed
US-4800166-A TRITYL HALIDE OR CARVOXYLATE TO BIND WITH FREE AMINO GROUPS APPLIED PROTEIN TECHNOLOGIES, INC. (US) 1989-01-24 US claimed
EP-0152459-B1 PROCESS FOR PRODUCING OLIGONUCLEOTIDES BIOSYNTECH Biochemische Synthesetechnik GmbH (DE) 1988-11-02 EP claimed
EP-0267996-A1 New nucleotide derivatives TAMIR BIOTECHNOLOGY LTD. (IL) 1988-05-25 EP claimed
US-4725677-A USING PHOSPHINE DERIVATIVE BIOSYNTECH GMBH (DE) 1988-02-16 US claimed
EP-0135587-A4 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1986-04-02 EP claimed
EP-0135587-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS. MOLECULAR BIOSYSTEMS INC (US) 1985-04-03 EP claimed
WO-1984003285-A1 DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS MOLECULAR BIOSYSTEMS INC (US) 1984-08-30 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240209016-A1 FLUORESCENT NUCLEOSIDE PHOSPHATES RNGTT, PNP, RNMT CA1 3658/4885CA2 1979/4885CA7 1462/4885
US-20240218365-A1 FORMULATION OF AN ANTISENSE OLIGOMER CONJUGATE POLB, GBA1, POLN CA1 4821/4885CA2 4807/4885CA7 4563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.