Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624290 | 0.91 | LTA4H (0.49) | LTA4HKCNH2HRH3NPC1ALDH1A1 | |
| SCHEMBL7642974 | 0.91 | KCNH2 (0.49) | LTA4HKCNH2HRH3NPC1ALDH1A1 | |
| SCHEMBL7619211 | 0.91 | S1PR5 (0.53) | LTA4HHRH3NPC1RAB9AKMT2A | |
| SCHEMBL7619864 | 0.87 | CCR8 (0.50) | ALDH1A1TSHRRAB9AKMT2APKM | |
| SCHEMBL7505933 | 0.85 | LTA4H (0.47) | LTA4HKCNH2HRH3NPC1ALDH1A1 | |
| SCHEMBL27555705 | 0.85 | S1PR5 (0.54) | KCNH2HRH3NPC1ALDH1A1RAB9A | |
| SCHEMBL6565485 | 0.85 | L3MBTL1 (0.50) | ALDH1A1KMT2APKMNPSR1L3MBTL1 | |
| SCHEMBL7987987 | 0.84 | KCNH2 (0.59) | LTA4HKCNH2HRH3NPC1ALDH1A1 | |
| SCHEMBL7555893 | 0.83 | S1PR5 (0.53) | HRH3ALDH1A1RAB9AKMT2AMEN1 | |
| SCHEMBL7509653 | 0.82 | CCR8 (0.49) | ALDH1A1KMT2AMEN1S1PR5MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |