Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957493 | 0.91 | POLB (0.53) | ALDH1A1MAPTTSHRNPSR1KMT2A | |
| SCHEMBL7950910 | 0.91 | TP53 (0.44) | ALDH1A1ACHEMAPTTSHRNPSR1 | |
| SCHEMBL5755654 | 0.90 | ALDH1A1 (0.51) | ALDH1A1ACHEMAPTTSHRPOLB | |
| SCHEMBL7944633 | 0.84 | TP53 (0.44) | ALDH1A1MAPTTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL7956984 | 0.83 | TP53 (0.41) | ALDH1A1MAPTTSHRNPSR1KMT2A | |
| SCHEMBL5755361 | 0.83 | ACHE (0.58) | ALDH1A1ACHEMAPTTSHRNPSR1 | |
| SCHEMBL7952239 | 0.83 | TP53 (0.41) | ALDH1A1MAPTTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL5754016 | 0.81 | ALDH1A1 (0.45) | ALDH1A1ACHEMAPTTSHRNPSR1 | |
| SCHEMBL5802067 | 0.78 | POLB (0.45) | ALDH1A1ACHEMAPTTSHRNPSR1 | |
| SCHEMBL5755628 | 0.75 | ABHD6 (0.41) | ACHEMAPTNPSR1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |