Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944633 | 0.90 | TP53 (0.44) | TP53KMT2AGAATSHRALOX15 | |
| SCHEMBL5756424 | 0.90 | KMT2A (0.36) | TP53KMT2AGAATSHRHSD17B10 | |
| SCHEMBL7956984 | 0.89 | TP53 (0.41) | TP53KMT2AGAATSHRALOX15 | |
| SCHEMBL7950910 | 0.86 | TP53 (0.44) | TP53GAATSHRSMN1; SMN2MAPT | |
| SCHEMBL7957493 | 0.86 | POLB (0.53) | TP53KMT2ATSHRALOX15SMN1; SMN2 | |
| SCHEMBL7952748 | 0.83 | ALDH1A1 (0.46) | TP53KMT2ATSHRALOX15SMN1; SMN2 | |
| SCHEMBL5755628 | 0.80 | ABHD6 (0.41) | KMT2AGAASMN1; SMN2MAPTHPGD | |
| SCHEMBL7141017 | 0.77 | ABHD6 (0.43) | KMT2ASMN1; SMN2MAPTHPGDKDM4E | |
| SCHEMBL5757388 | 0.77 | RAB9A (0.40) | TP53GAASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7950977 | 0.75 | AGER (0.37) | TP53KMT2AGAAALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |