Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | S100A4 | P26447 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562005 | 0.82 | GPR3 (0.46) | MEN1KMT2APOLBCYP1A2CYP2D6 | |
| SCHEMBL17262530 | 0.80 | ACHE (0.38) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL28069840 | 0.80 | CYP2D6 (0.50) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL19926520 | 0.78 | MEN1 (0.42) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL28225291 | 0.76 | EDNRB (0.44) | MEN1KMT2APOLBCYP1A2LMNA | |
| SCHEMBL29285411 | 0.74 | MAPK1 (0.44) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL15449470 | 0.72 | MEN1 (0.46) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL7959774 | 0.70 | MAPK1 (0.44) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL12460888 | 0.70 | EDNRB (0.43) | MEN1KMT2AS100A4POLBMAPK1 | |
| SCHEMBL28228764 | 0.69 | KMT2A (0.55) | MEN1KMT2AS100A4POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423069-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| US-12071411-B2 | Inhibitors of HIF-2α and methods of use thereof | ARCUS BIOSCIENCES, INC. (US) | 2024-08-27 | — | — | US | disclosed |
| US-20230159466-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. | 2023-05-25 | — | — | US | disclosed |
| WO-2023077046-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| US-20180273573-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356447-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | Memorial Sloan-Kettering Cancer Center (US) | 2018-08-08 | — | — | EP | disclosed |
| WO-2017059411-A9 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-08-31 | — | — | WO | disclosed |
| US-6271421-B1 | CONTACTING AN ALPHA-POLYBROMINATED KETONE WITH AN ALKALI METAL SULFITE IN THE PRESENCE OF A C2-C6 ALKYLCARBOXYLIC ACID TO OBTAIN A SELECTIVELY MONO-DEBROMINATED PRODUCT. | MERCK & CO., INC. | 2001-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12071411-B2 | Inhibitors of HIF-2α and methods of use thereof | HIF1AN, HIF1A, EGLN2 | MEN1 4122/4885KMT2A 797/4885S100A4 4264/4885 |
| US-20230159466-A1 | INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | MEN1 4224/4885KMT2A 653/4885S100A4 4193/4885 |
| US-20180273573-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | COASY, SDHA, VKORC1 | MEN1 79/4885KMT2A 2343/4885S100A4 4184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.