Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.52 |
| ▸ | CA2 | P00918 | 16/20 | 0.52 |
| ▸ | CA4 | P22748 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 13/20 | 0.52 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA6 | P23280 | 4/20 | 0.42 |
| ▸ | CA5A | P35218 | 4/20 | 0.42 |
| ▸ | CA7 | P43166 | 4/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952991 | 0.81 | APEX1 (0.67) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL11129317 | 0.75 | CYP3A4 (0.45) | CA1CA2CA9TDP1ALDH1A1 | |
| SCHEMBL3776806 | 0.73 | CA1 (0.45) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL3767971 | 0.73 | CA1 (0.46) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL2919577 | 0.73 | CA2 (0.48) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL7371363 | 0.71 | VCAM1 (0.47) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL20279804 | 0.70 | ALDH1A1 (0.41) | CA1CA2CA9TDP1ALDH1A1 | |
| SCHEMBL10796712 | 0.70 | CA1 (0.50) | CA1CA2CA9CA3 | |
| SCHEMBL11038427 | 0.69 | CA1 (0.71) | CA1CA2CA4CA9APEX1 | |
| SCHEMBL2766389 | 0.69 | CA1 (0.52) | CA1CA2CA9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457906-A1 | Derivatives of 1,2,4-benzothiadiazine dioxide, their preparation and use as allosteric modulators of the AMPA receptor | Universita'del Salento (IT) | 2012-05-30 | — | — | EP | disclosed |