Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PLD2 | O14939 | 1/20 | 0.43 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23095941 | 0.75 | ALDH1A1 (0.48) | EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13093209 | 0.73 | TP53 (0.46) | MDM2 | |
| SCHEMBL7958438 | 0.71 | MDM2 (0.50) | MDM2ALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL13093203 | 0.70 | HTT (0.47) | MDM2 | |
| SCHEMBL18568205 | 0.70 | EPHX2 (0.47) | SIGMAR1EPHX2ALDH1A1 | |
| SCHEMBL12446087 | 0.70 | MDM2 (0.44) | PLD2PLD1MDM2ALDH1A1GAA | |
| SCHEMBL12446511 | 0.68 | MDM2 (0.54) | EPHX2MDM2ALDH1A1CNR1SMN1; SMN2 | |
| SCHEMBL13093053 | 0.67 | SLC6A4 (0.44) | — | |
| SCHEMBL13092987 | 0.67 | SLC6A4 (0.44) | — | |
| SCHEMBL4870310 | 0.66 | SIGMAR1 (1.00) | SIGMAR1PLD2PLD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |