Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951910 | 0.81 | TP53 (0.43) | MDM2ALDH1A1HTR1AHTTKDM4E | |
| SCHEMBL12446511 | 0.77 | MDM2 (0.54) | MDM2LMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL7953306 | 0.71 | SIGMAR1 (0.49) | MDM2SMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL18772867 | 0.71 | MDM2 (0.70) | MDM2TP53 | |
| Hydrochloric Acid SCHEMBL4934601 | 0.70 | LMNA (0.48) | LMNASMN1; SMN2KMT2AALDH1A1HTR1A | |
| SCHEMBL12446087 | 0.67 | MDM2 (0.44) | MDM2ALDH1A1KDM4ETP53 | |
| SCHEMBL8771374 | 0.67 | CYP2C19 (0.69) | LMNASMN1; SMN2KMT2AALDH1A1HTR1A | |
| SCHEMBL22778764 | 0.66 | ALDH1A1 (0.46) | LMNAALDH1A1CD274KDM4ETSHR | |
| SCHEMBL4871963 | 0.65 | SIGMAR1 (0.79) | LMNAALDH1A1CD274KDM4ETSHR | |
| SCHEMBL17554100 | 0.65 | HTT (0.75) | KMT2AALDH1A1HTR1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010031713-A1 | SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |