Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13093209 | 0.82 | TP53 (0.46) | SLC6A3SLC9A1MDM2TP53SLC6A2 | |
| SCHEMBL23095941 | 0.77 | ALDH1A1 (0.48) | HTT | |
| SCHEMBL13093287 | 0.71 | SLC6A3 (0.45) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7953306 | 0.70 | SIGMAR1 (0.49) | MDM2 | |
| SCHEMBL31177085 | 0.70 | HTR3E (0.43) | HTTTP53 | |
| SCHEMBL31176968 | 0.70 | HTR3E (0.43) | HTTTP53 | |
| SCHEMBL12446512 | 0.69 | HTT (0.46) | HTTSLC9A1MDM2TP53 | |
| SCHEMBL8329086 | 0.69 | SLC9A1 (0.44) | HTTSLC6A3SLC9A1SLC6A2SLC6A4 | |
| SCHEMBL13093492 | 0.69 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27743611 | 0.69 | TP53 (0.39) | HTTSLC6A3SLC9A1MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123006-A1 | PYRROLIDINE COMPOUND | 武田薬品工業株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |