Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590022 | 0.88 | CYP11B2 (0.38) | CYP11B2CYP11B1ALDH1A1RECQLABCC1 | |
| SCHEMBL7592203 | 0.85 | CNR2 (0.37) | CYP11B2CYP11B1ALDH1A1RECQLABCC1 | |
| SCHEMBL8331687 | 0.77 | CYP11B2 (0.41) | CYP11B2CYP11B1RECQLLRRK2PDE4B | |
| SCHEMBL7946519 | 0.76 | PLAU (0.41) | ABCC1RORCPPARGCLK2CLK3 | |
| SCHEMBL2157932 | 0.75 | ALDH1A1 (0.40) | CYP11B2CYP11B1ALDH1A1ABCC1 | |
| SCHEMBL7946444 | 0.75 | ALDH1A1 (0.43) | CYP11B2ALDH1A1RECQLABCC1ABCG2 | |
| SCHEMBL7953580 | 0.74 | CYP11B1 (0.37) | CYP11B2CYP11B1ALDH1A1RECQLABCC1 | |
| SCHEMBL7955650 | 0.74 | ABCC1 (0.42) | CYP11B2ALDH1A1RECQLABCC1ABCG2 | |
| SCHEMBL7946457 | 0.74 | ALDH1A1 (0.42) | CYP11B2ALDH1A1RECQLABCC1ABCG2 | |
| SCHEMBL2157447 | 0.73 | CYP11B2 (0.43) | CYP11B2CYP11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |