Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | IAPP | P10997 | 4/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274458 | 0.83 | ALDH1A1 (0.51) | HMGB1IAPPALOX5PTGS2PRKCI | |
| SCHEMBL14588767 | 0.82 | HMGB1 (0.49) | HMGB1IAPPALOX5PTGS2PRKCI | |
| SCHEMBL9740139 | 0.81 | HMGB1 (0.47) | HMGB1IAPPALOX5PTGS2PRKCI | |
| SCHEMBL7028825 | 0.79 | HMGB1 (0.51) | HMGB1IAPPALOX5PTGS2PRKCI | |
| SCHEMBL3690730 | 0.78 | KDM4E (0.50) | HMGB1ALDH1A1LMNAKDM4EHSD17B10 | |
| SCHEMBL8124725 | 0.77 | PRKCI (0.54) | HMGB1IAPPALOX5PTGS2PRKCI | |
| SCHEMBL9859 | 0.77 | HMGB1 (0.69) | HMGB1IAPPPRKCIGABRA1GABRB2 | |
| SCHEMBL24754424 | 0.76 | KMT2A (0.43) | ALDH1A1LMNAKDM4EPOLBHSD17B10 | |
| SCHEMBL17047941 | 0.76 | HMGB1 (0.46) | HMGB1IAPPALOX5PTGS2PRKCI | |
| Bicarbonate SCHEMBL22573123 | 0.76 | HMGB1 (0.67) | HMGB1IAPPPRKCIGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218427-B1 | AS ENDOTHELIN RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-0924207-A1 | CHROMENE-3-CARBOXYLATE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |