Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30097124 | 0.88 | RAB9A (0.78) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL31344832 | 0.86 | RAB9A (0.63) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL20134872 | 0.77 | MPO (0.49) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL374150 | 0.77 | SOS1 (0.51) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2859330 | 0.77 | MPO (0.67) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL23411619 | 0.77 | MPO (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1MPO | |
| SCHEMBL14157509 | 0.77 | MPO (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1MPO | |
| SCHEMBL7964498 | 0.77 | MPO (0.49) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2243120 | 0.76 | RAB9A (1.00) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL7955486 | 0.76 | BCHE (0.57) | RAB9AMAPTKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |