Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965790 | 0.85 | KCNMA1 (0.41) | MAPTHTTALDH1A1NPC1RAB9A | |
| SCHEMBL7423430 | 0.84 | PIK3CA (0.36) | MAPTHTTCHEK1ALDH1A1PIK3CA | |
| SCHEMBL7967008 | 0.84 | PIK3CA (0.36) | LMNAMAPTCHEK1ALDH1A1RAB9A | |
| SCHEMBL7964711 | 0.82 | PDE5A (0.49) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7967293 | 0.82 | KCNMA1 (0.38) | MAPTHTTALDH1A1NPC1RAB9A | |
| SCHEMBL7371553 | 0.77 | ALDH1A1 (0.46) | LMNAMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7371278 | 0.76 | ALDH1A1 (0.44) | LMNAMAPTALDH1A1SMN1; SMN2GPBAR1 | |
| SCHEMBL7963323 | 0.75 | DHODH (0.37) | MAPTHTTALDH1A1TSHR | |
| SCHEMBL7485636 | 0.75 | PIK3CA (0.35) | MAPTHTTCHEK1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7594361 | 0.74 | DHODH (0.36) | MAPTHTTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |