Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423430 | 0.93 | PIK3CA (0.36) | PIK3CAGPBAR1CHEK1KDM4EALDH1A1 | |
| SCHEMBL7954388 | 0.84 | LMNA (0.40) | PIK3CAGPBAR1LMNARAB9ACHEK1 | |
| SCHEMBL7421586 | 0.83 | TUBB4A (0.42) | PIK3CAGPBAR1LMNARAB9AACLY | |
| SCHEMBL7969332 | 0.82 | PIK3CA (0.37) | PIK3CAGPBAR1RAB9AACLYLPAR1 | |
| SCHEMBL7594101 | 0.81 | BRD4 (0.40) | LMNARAB9AMAPT | |
| SCHEMBL7485636 | 0.81 | PIK3CA (0.35) | PIK3CAGPBAR1RAB9ACHEK1KDM4E | |
| Hydrochloric Acid SCHEMBL7969803 | 0.80 | BRD4 (0.40) | LMNARAB9AMAPT | |
| SCHEMBL7534090 | 0.77 | RXFP1 (0.33) | LMNARAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL7963323 | 0.77 | DHODH (0.37) | ALDH1A1MAPT | |
| SCHEMBL7965790 | 0.77 | KCNMA1 (0.41) | RAB9AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |