SCHEMBL7963323

SCHEMBL7963323

COc1cc(C(=O)N(C)c2ccccc2C2=NC(C)(C)CO2)ccc1NC(=O)c1cccc2[nH]c(C)nc12

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.37
IRAK4 Q9NWZ3 1/20 0.36
TYK2 P29597 1/20 0.35
TP53 P04637 2/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
ALDH1A1 P00352 1/20 0.34
PARP1 P09874 2/20 0.34
RXFP1 Q9HBX9 1/20 0.34
KCNMA1 Q12791 1/20 0.34
CASP3 P42574 1/20 0.34
MAPT P10636 1/20 0.34
HDAC8 Q9BY41 1/20 0.33
TOP1 P11387 1/20 0.33
AVPR2 P30518 1/20 0.33
AVPR1A P37288 1/20 0.33
AVPR1B P47901 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7594361 0.99 DHODH (0.36) DHODHIRAK4TYK2TP53TSHR
SCHEMBL7597506 0.83 RAB9A (0.34) DHODHTP53TSHRHTTALDH1A1
Hydrochloric Acid SCHEMBL7593069 0.83 PTGES (0.35) IRAK4TP53TSHRHTTALDH1A1
Hydrochloric Acid SCHEMBL7970610 0.82 RAB9A (0.33) DHODHTP53TSHRHTTALDH1A1
SCHEMBL7594101 0.82 BRD4 (0.40) IRAK4TP53RXFP1CASP3MAPT
SCHEMBL7965790 0.81 KCNMA1 (0.41) HTTALDH1A1KCNMA1MAPT
Hydrochloric Acid SCHEMBL7969803 0.81 BRD4 (0.40) IRAK4TP53RXFP1CASP3MAPT
SCHEMBL7953969 0.81 TUBB4A (0.40) DHODHTP53TSHRHTTALDH1A1
Hydrochloric Acid SCHEMBL7593255 0.81 TUBB4A (0.39) DHODHIRAK4TP53TSHRHTT
SCHEMBL7481778 0.81 BRPF1 (0.44) IRAK4TP53TSHRHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6316482-B1 FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-11-13 US disclosed
US-6207693-B1 Benzamide derivatives having a vasopressin antagonistic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-03-27 US disclosed