Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 11/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967300 | 0.79 | TLR9 (0.43) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL30718696 | 0.78 | BACE1 (0.45) | TLR9TLR8TLR7SLC6A4MEN1 | |
| SCHEMBL27146850 | 0.78 | BACE1 (0.45) | TLR9TLR8TLR7SLC6A4MEN1 | |
| SCHEMBL7971282 | 0.75 | RAB9A (0.64) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL29733200 | 0.73 | MEN1 (0.57) | SLC6A4MEN1KMT2AHRH4NPC1 | |
| SCHEMBL21000902 | 0.73 | MEN1 (0.57) | SLC6A4MEN1KMT2AHRH4NPC1 | |
| SCHEMBL21979975 | 0.71 | TLR8 (0.47) | TLR8KCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL28388238 | 0.70 | TLR8 (0.47) | TLR8KCNH2HRH3 | |
| SCHEMBL7955026 | 0.70 | MEN1 (0.42) | TLR9TLR8TLR7MEN1KMT2A | |
| SCHEMBL19411398 | 0.70 | BACE1 (0.43) | TLR9TLR8TLR7SLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |