Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.46 |
| ▸ | BCHE | P06276 | 6/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955279 | 1.00 | ACHE (0.46) | ACHEBCHECHRNB2CHRNA4GAA | |
| SCHEMBL7955274 | 1.00 | ACHE (0.46) | ACHEBCHECHRNB2CHRNA4GAA | |
| SCHEMBL7955710 | 0.80 | GAA (0.46) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A | |
| SCHEMBL5758570 | 0.80 | GAA (0.46) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A | |
| SCHEMBL7955713 | 0.80 | GAA (0.46) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A | |
| SCHEMBL10903048 | 0.70 | ACHE (0.56) | ACHEBCHECHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL7967588 | 0.70 | ALDH1A1 (0.40) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A | |
| SCHEMBL9936009 | 0.70 | GPR119 (0.53) | ACHEBCHECHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL5697246 | 0.70 | ALDH1A1 (0.68) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A | |
| SCHEMBL6161213 | 0.69 | ALDH1A1 (0.62) | GAAALDH1A1SMN1; SMN2CHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |