Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.49 |
| ▸ | GBA1 | P04062 | 3/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956152 | 0.85 | ACACB (0.52) | ACACBFFAR4CYP11B2PDE3BPDE3A | |
| SCHEMBL7956714 | 0.84 | ACACB (0.60) | ACACBFFAR4 | |
| SCHEMBL7956662 | 0.83 | ACACB (0.55) | ACACBCYP11B2PDE3BPDE3APDE10A | |
| SCHEMBL7956861 | 0.83 | ACACB (0.51) | ACACBFFAR4CYP11B2PDE3BPDE3A | |
| SCHEMBL7955317 | 0.83 | HRH1 (0.47) | ACACBGBA1FFAR4CYP11B2PDE10A | |
| SCHEMBL7958655 | 0.81 | LIPG (0.50) | ACACB | |
| SCHEMBL13406711 | 0.81 | HRH3 (0.52) | ACACBFFAR4NAAA | |
| SCHEMBL7961508 | 0.80 | ACACB (0.51) | ACACBFFAR4PDE3BPDE3APDE10A | |
| SCHEMBL7956683 | 0.80 | HRH3 (0.58) | ACACBPDE3BPDE3APDE10A | |
| SCHEMBL7961730 | 0.80 | ACACB (0.51) | ACACBCYP11B2PDE3BPDE3APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |