Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 16/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956152 | 0.83 | ACACB (0.52) | ACACBFFAR4PDE3BPDE3APDE10A | |
| SCHEMBL7956861 | 0.82 | ACACB (0.51) | ACACBFFAR4PDE3BPDE3APDE10A | |
| SCHEMBL7956662 | 0.82 | ACACB (0.55) | ACACBPDE3BPDE3APDE10A | |
| SCHEMBL7961730 | 0.82 | ACACB (0.51) | ACACBPDE3BPDE3APDE10A | |
| SCHEMBL7956496 | 0.82 | PDE3B (0.51) | ACACBPDE3BPDE3APDE10A | |
| SCHEMBL7956714 | 0.80 | ACACB (0.60) | ACACBFFAR4 | |
| SCHEMBL7958655 | 0.80 | LIPG (0.50) | ACACB | |
| SCHEMBL7955313 | 0.80 | ACACB (0.49) | ACACBFFAR4PDE3BPDE3APDE10A | |
| SCHEMBL7956683 | 0.79 | HRH3 (0.58) | ACACBPDE3BPDE3APDE10A | |
| SCHEMBL17308381 | 0.77 | ADRB2 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |