Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.60 |
| ▸ | F10 | P00742 | 4/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961303 | 0.93 | F10 (0.54) | ACACBF10MCHR1FFAR4HRH1 | |
| SCHEMBL7956699 | 0.88 | ACACB (0.48) | ACACBF10MCHR1FFAR4 | |
| SCHEMBL7955313 | 0.84 | ACACB (0.49) | ACACBFFAR4 | |
| SCHEMBL7961508 | 0.80 | ACACB (0.51) | ACACBFFAR4 | |
| SCHEMBL7956152 | 0.79 | ACACB (0.52) | ACACBFFAR4 | |
| SCHEMBL7956662 | 0.78 | ACACB (0.55) | ACACBHRH1HRH3 | |
| SCHEMBL7956861 | 0.78 | ACACB (0.51) | ACACBFFAR4 | |
| SCHEMBL7961307 | 0.78 | F10 (0.52) | F10HRH1HRH3F2 | |
| SCHEMBL7956683 | 0.78 | HRH3 (0.58) | ACACBHRH1HRH3 | |
| SCHEMBL7958655 | 0.76 | LIPG (0.50) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |