Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 12/20 | 0.47 |
| ▸ | MMP3 | P08254 | 11/20 | 0.47 |
| ▸ | MMP7 | P09237 | 9/20 | 0.47 |
| ▸ | FCER2 | P06734 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 12/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955450 | 1.00 | MMP2 (0.47) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7835182 | 0.87 | MMP2 (0.41) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7946622 | 0.87 | MMP2 (0.41) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7946619 | 0.87 | MMP2 (0.41) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7955728 | 0.82 | MMP1 (0.47) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL27449166 | 0.82 | MMP1 (0.47) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7840632 | 0.82 | MMP1 (0.47) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7839520 | 0.82 | MMP1 (0.47) | MMP2MMP3MMP7FCER2MMP1 | |
| SCHEMBL7955767 | 0.82 | ITGB1 (0.36) | MMP2MMP3MMP7MMEACE | |
| SCHEMBL6220773 | 0.81 | ADAM17 (0.55) | MMP2MMP3MMP7FCER2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |