Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 4/20 | 0.34 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | CPA1 | P15085 | 3/20 | 0.34 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946705 | 0.89 | ITGB1 (0.34) | ITGB1ITGA4MMEACECPA1 | |
| SCHEMBL7828157 | 0.85 | ADAM17 (0.39) | SRCMMP2MMP3MMP7 | |
| SCHEMBL7955448 | 0.82 | MMP2 (0.47) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7955450 | 0.82 | MMP2 (0.47) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL6220706 | 0.80 | BMP1 (0.33) | MMP2MMP3MMP7 | |
| SCHEMBL6221034 | 0.80 | MMP1 (0.38) | MMP2MMP3MMP7 | |
| SCHEMBL7955118 | 0.80 | MMP1 (0.37) | MMP2MMP3MMP7 | |
| SCHEMBL6946529 | 0.75 | ADAM17 (0.40) | MGLLMMP2MMP3MMP7 | |
| SCHEMBL6946530 | 0.75 | ADAM17 (0.40) | MGLLMMP2MMP3MMP7 | |
| SCHEMBL7946535 | 0.74 | MMP1 (0.37) | MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |