Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUND | P17535 | 1/20 | 0.38 |
| ▸ | FOSB | P53539 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966223 | 0.79 | HTR2C (0.46) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL7967919 | 0.76 | JUND (0.39) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL7964862 | 0.76 | JUND (0.39) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL6665906 | 0.76 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3703851 | 0.75 | HTR1A (0.44) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7955565 | 0.71 | BCHE (0.51) | JUNDFOSBHTR2CHTR1ASLC6A2 | |
| SCHEMBL373467 | 0.69 | BCHE (0.44) | HTR2CHTR1A | |
| SCHEMBL5995383 | 0.68 | BCHE (0.43) | HTR1A | |
| Hydrochloric Acid SCHEMBL1545403 | 0.68 | BCHE (0.43) | HTR2CHTR1A | |
| SCHEMBL13201094 | 0.68 | JUND (0.51) | JUNDFOSBHTR2CHTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |