Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507776 | 0.89 | OPRK1 (0.42) | OPRK1CYP2D6OPRD1OPRM1CCR5 | |
| SCHEMBL6984388 | 0.88 | CCR5 (0.45) | OPRK1CYP2D6OPRD1OPRM1CCR5 | |
| SCHEMBL8507116 | 0.86 | OPRD1 (0.47) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL7986058 | 0.86 | OPRK1 (0.43) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL8507786 | 0.86 | OPRK1 (0.46) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL7838464 | 0.84 | OPRK1 (0.43) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL8508097 | 0.83 | ALDH1A1 (0.45) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL8508021 | 0.83 | OPRK1 (0.43) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL7844738 | 0.83 | OPRK1 (0.42) | OPRK1CYP2D6OPRD1OPRM1 | |
| SCHEMBL8506648 | 0.83 | OPRK1 (0.44) | OPRK1CYP2D6OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307061-B2 | USEFUL AS AN ANALGESIC, ANESTHETIC, ANTI-INFLAMMATORY OR NEUROPROTECIVE AGENT | PFIZER INC. | 2001-10-23 | — | — | US | disclosed |
| US-6294557-B1 | ANALGESIC AT CENTRAL NERVOUS SYSTEM IN THE MAMMALIAN SUBJECT. ALSO, THESE COMPOUNDS ARE INFLAMMATORY PAIN CAUSED, FOR EXAMPLE BY BURNS (INDUCED BY A CONTACT WITH HEAT, ACID OR THE OTHER RHEUMATISM OR THE LIKE, IN THE SAID SUBJECT. | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |