Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5968972 | 0.82 | KMT2A (0.46) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL5968978 | 0.82 | KMT2A (0.46) | KMT2AMEN1CA1CA2MMP1 | |
| SCHEMBL7955716 | 0.81 | ALDH1A1 (0.48) | KMT2AMEN1THRBCA1CA2 | |
| SCHEMBL7955761 | 0.81 | ALDH1A1 (0.48) | KMT2AMEN1THRBCA1CA2 | |
| SCHEMBL9776653 | 0.76 | KMT2A (0.45) | KMT2AMEN1THRBGAACA1 | |
| SCHEMBL7955714 | 0.73 | KMT2A (0.39) | KMT2AMEN1THRBPKMGAA | |
| SCHEMBL8731526 | 0.70 | ALDH1A1 (0.44) | KMT2AMEN1THRBLMNA | |
| SCHEMBL10711121 | 0.69 | SMN1; SMN2 (0.49) | KMT2AMEN1THRBPKMGAA | |
| SCHEMBL8713493 | 0.69 | KMT2A (0.58) | KMT2AMEN1THRBPKMGAA | |
| SCHEMBL19469362 | 0.69 | KMT2A (0.58) | KMT2AMEN1THRBPKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172238-B1 | Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]propionyl]piperidine | HOFFMANN-LA ROCHE INC. | 2001-01-09 | — | — | US | claimed |