Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711121 | 0.75 | SMN1; SMN2 (0.49) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL7955717 | 0.73 | KMT2A (0.38) | KMT2AMEN1THRBCA1CA2 | |
| SCHEMBL19469362 | 0.73 | KMT2A (0.58) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL8713493 | 0.73 | KMT2A (0.58) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL9098667 | 0.68 | KMT2A (0.51) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL28046418 | 0.67 | ALDH1A1 (0.51) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL28899438 | 0.66 | KMT2A (0.45) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL7969864 | 0.66 | L3MBTL1 (0.41) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL7066685 | 0.66 | KMT2A (0.40) | KMT2AMEN1THRBALDH1A1CA1 | |
| SCHEMBL9509278 | 0.65 | KMT2A (0.47) | KMT2AMEN1THRBALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172238-B1 | Process for manufacturing 1-[3-cyclopentyl-2(R)-[1(R)-hydroxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]propionyl]piperidine | HOFFMANN-LA ROCHE INC. | 2001-01-09 | — | — | US | claimed |