Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260858 | 0.81 | OPRM1 (0.50) | OPRM1TEAD1CHRM2CHRM1CHRM3 | |
| SCHEMBL27261780 | 0.78 | CYP2D6 (0.42) | OPRM1TEAD1CHRM2CHRM1CHRM4 | |
| SCHEMBL19538662 | 0.75 | HRH3 (0.61) | — | |
| SCHEMBL1677054 | 0.74 | EPHX2 (0.52) | OPRM1 | |
| SCHEMBL14699678 | 0.73 | ALDH1A1 (0.65) | HCRTR1TEAD1CHRM2CHRM1CARM1 | |
| SCHEMBL7956021 | 0.73 | CARM1 (0.40) | HSD11B1CARM1PRMT6FPR2PROKR1 | |
| SCHEMBL7961313 | 0.72 | SLC6A4 (0.45) | CARM1PRMT6 | |
| SCHEMBL7945321 | 0.71 | CARM1 (0.39) | HCRTR1GPR139CARM1PRMT6FPR2 | |
| SCHEMBL7950089 | 0.71 | CARM1 (0.39) | HCRTR1GPR139CARM1PRMT6FPR2 | |
| SCHEMBL7949461 | 0.71 | HSD11B1 (0.60) | HSD11B1FPR2PROKR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346820-B1 | OXYCARBAMOYL COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO (JP) | 2013-02-13 | — | — | EP | disclosed |
| WO-2009151152-A1 | OXYCARBAMOYL COMPOUNDS AND THE USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2009-12-17 | — | — | WO | disclosed |