Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 4/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835837 | 1.00 | ACHE (0.36) | ACHECTSKCTSLCTSBCTSS | |
| SCHEMBL7836363 | 0.93 | MMP1 (0.43) | MMP1MMP13MMP3MMP8HDAC6 | |
| SCHEMBL7955049 | 0.93 | MMP1 (0.43) | MMP1MMP13MMP3MMP8HDAC6 | |
| SCHEMBL7837319 | 0.89 | CTSL (0.38) | ACHECTSKCTSLCTSBCTSS | |
| SCHEMBL7828548 | 0.89 | CTSL (0.38) | ACHECTSKCTSLCTSBCTSS | |
| SCHEMBL7946730 | 0.82 | APP (0.49) | MMP1MMP13MMP3MMP8HDAC6 | |
| SCHEMBL7946731 | 0.82 | APP (0.49) | MMP1MMP13MMP3MMP8HDAC6 | |
| SCHEMBL7838516 | 0.76 | MMP1 (0.41) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7838513 | 0.76 | MMP1 (0.41) | MMP1MMP13MMP3MMP8MMP2 | |
| SCHEMBL7957589 | 0.76 | MMP1 (0.41) | MMP1MMP13MMP3MMP8MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |