Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.49 |
| ▸ | TYMS | P04818 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965270 | 0.92 | DHFR (0.47) | DHFRTYMSMMP2MMP3MMP9 | |
| SCHEMBL7956310 | 0.83 | DHFR (0.44) | DHFRTYMSWDR5ALDH1A1UTS2R | |
| SCHEMBL7966642 | 0.78 | CYP1A2 (0.41) | DHFRTYMSHSP90AA1MMP2MMP3 | |
| SCHEMBL6932601 | 0.77 | CFTR (0.43) | DHFRTYMSHSP90AA1MMP2MMP3 | |
| SCHEMBL7968559 | 0.77 | DHFR (0.39) | DHFRTYMSALDH1A1UTS2RKDM4E | |
| SCHEMBL6026158 | 0.76 | CFTR (0.50) | DHFRTYMSHSP90AA1ALDH1A1ALOX15 | |
| SCHEMBL7956413 | 0.72 | CFTR (0.39) | DHFRTYMSHSP90AA1MMP2MMP3 | |
| SCHEMBL6026268 | 0.72 | CFTR (0.39) | TYMSHSP90AA1MMP2MMP3MMP9 | |
| SCHEMBL30901483 | 0.71 | CYP2A6 (0.52) | WDR5ALDH1A1TSHRHSD17B10 | |
| SCHEMBL29242851 | 0.71 | CYP2A6 (0.52) | WDR5ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265436-B1 | ANTIINFLAMMATORY AGENTS | OXIS THERAPEUTICS INC. | 2001-07-24 | — | — | US | disclosed |