Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.47 |
| ▸ | TYMS | P04818 | 2/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955950 | 0.92 | DHFR (0.49) | DHFRTYMSUTS2RMMP2MMP3 | |
| SCHEMBL7956310 | 0.83 | DHFR (0.44) | DHFRTYMSNPC1RAB9AUTS2R | |
| SCHEMBL6026268 | 0.78 | CFTR (0.39) | TYMSNPC1RAB9AMMP2MMP3 | |
| SCHEMBL7971973 | 0.75 | GPR84 (0.39) | DHFRTYMSGPR84MMP2MMP3 | |
| SCHEMBL7968559 | 0.74 | DHFR (0.39) | DHFRTYMSNPC1UTS2RTP53 | |
| SCHEMBL7586371 | 0.71 | AKR1C2 (0.41) | DHFRTYMSLMNAALOX12 | |
| SCHEMBL6934449 | 0.71 | AKR1C2 (0.41) | DHFRTYMSLMNAALOX12 | |
| SCHEMBL7966642 | 0.70 | CYP1A2 (0.41) | DHFRTYMSNPC1RAB9AMMP2 | |
| SCHEMBL6932601 | 0.69 | CFTR (0.43) | DHFRTYMSMMP2MMP3MMP9 | |
| SCHEMBL6026174 | 0.68 | ESR2 (0.40) | TYMSMMP2MMP3MMP9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265436-B1 | ANTIINFLAMMATORY AGENTS | OXIS THERAPEUTICS INC. | 2001-07-24 | — | — | US | disclosed |