Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567555 | 0.96 | MEN1 (0.54) | MMP1MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7345881 | 0.88 | S1PR5 (0.60) | MMP1MMP9MMP13ADAM17HRH3 | |
| SCHEMBL7355241 | 0.85 | KDM4E (0.67) | MMP1MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7509075 | 0.83 | MMP1 (0.61) | MMP1MMP9MMP13ADAM17MEN1 | |
| SCHEMBL7347681 | 0.81 | ALDH1A1 (0.64) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7506962 | 0.80 | MMP1 (0.54) | MMP1MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL493434 | 0.80 | MEN1 (0.61) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7998480 | 0.80 | OPRM1 (0.55) | MMP1MMP9MMP13ADAM17MEN1 | |
| SCHEMBL6988354 | 0.79 | KDM4E (0.74) | HRH3MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7353607 | 0.78 | S1PR5 (0.58) | MMP1MMP9MMP13ADAM17HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |