Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956244 | 0.84 | CYP19A1 (0.65) | ALDH1A1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL7958990 | 0.84 | ALDH1A1 (0.60) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL27083321 | 0.84 | LMNA (0.61) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL3923271 | 0.84 | SMN1; SMN2 (0.71) | ALDH1A1SMN1; SMN2LMNAHTTCYP19A1 | |
| SCHEMBL27083314 | 0.84 | POLB (0.61) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL27083342 | 0.83 | LMNA (0.59) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL7956458 | 0.82 | POLB (0.51) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL27083364 | 0.82 | HTT (0.61) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL7956456 | 0.81 | RAB9A (0.49) | ALDH1A1MAPTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL27083383 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |