Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.79 |
| ▸ | MAOA | P21397 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MDH2 | P40926 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24471022 | 0.91 | MAOB (0.66) | MAOBMAOAALDH1A1HPGDMDH2 | |
| SCHEMBL26103188 | 0.90 | MAOB (0.65) | MAOBMAOAALDH1A1HPGDMDH2 | |
| SCHEMBL7950720 | 0.88 | MAOB (0.79) | MAOBMAOAMEN1KMT2APKM | |
| SCHEMBL27516742 | 0.83 | MAOB (0.58) | MAOBMAOASLC16A3PKML3MBTL1 | |
| SCHEMBL27516743 | 0.83 | MAOA (0.57) | MAOBMAOAMEN1KMT2APKM | |
| SCHEMBL6720384 | 0.82 | MAOB (0.61) | MAOBMAOAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7952747 | 0.80 | MAOA (0.77) | MAOBMAOAPKML3MBTL1CASP3 | |
| SCHEMBL24470811 | 0.80 | MAOB (0.60) | MAOBMAOAMEN1KMT2APKM | |
| SCHEMBL30569409 | 0.80 | MAOB (0.60) | MAOBMAOAMEN1KMT2APKM | |
| SCHEMBL26105385 | 0.80 | MAOA (0.56) | MAOBMAOAALDH1A1HPGDMDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218427-B1 | AS ENDOTHELIN RECEPTOR ANTAGONIST | SHIONOGI & CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| CN-1234029-A | Chromene-3-carboxylate derivative | SHIONOGI & CO (JP) | 1999-11-03 | — | — | CN | disclosed |
| EP-0924207-A1 | CHROMENE-3-CARBOXYLATE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |